Impact of Hypoxia on Drug Resistance and Growth Characteristics of Mycobacterium tuberculosis Clinical Isolates

Zhonghua Liu; Yulu Gao; Hua Yang; Haiyang Bao; Lianhua Qin; Changtai Zhu; Yawen Chen; Zhongyi Hu

doi:10.1371/journal.pone.0166052

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Open Access

Peer-reviewed

Research Article

Impact of Hypoxia on Drug Resistance and Growth Characteristics of Mycobacterium tuberculosis Clinical Isolates

Zhonghua Liu ,

Contributed equally to this work with: Zhonghua Liu, Yulu Gao, Hua Yang

Affiliation Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Yulu Gao ,

Contributed equally to this work with: Zhonghua Liu, Yulu Gao, Hua Yang

Affiliation Department of Laboratory Medicine, Kunshan Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Kunshan, China
⨯
Hua Yang ,

Contributed equally to this work with: Zhonghua Liu, Yulu Gao, Hua Yang

Affiliation Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Haiyang Bao,

Affiliation Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Lianhua Qin,

Affiliation Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Changtai Zhu ,

* E-mail: zct101@163.com (CTZ); yawenchen2211@163.com (YWC); shhuzy@163.com (ZYH)

Affiliation Department of Transfusion, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
⨯
Yawen Chen ,

* E-mail: zct101@163.com (CTZ); yawenchen2211@163.com (YWC); shhuzy@163.com (ZYH)

Affiliation Department of Nursing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
⨯
Zhongyi Hu

* E-mail: zct101@163.com (CTZ); yawenchen2211@163.com (YWC); shhuzy@163.com (ZYH)

Affiliation Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
⨯

Impact of Hypoxia on Drug Resistance and Growth Characteristics of Mycobacterium tuberculosis Clinical Isolates

Zhonghua Liu,
Yulu Gao,
Hua Yang,
Haiyang Bao,
Lianhua Qin,
Changtai Zhu,
Yawen Chen,
Zhongyi Hu

Published: November 11, 2016
https://doi.org/10.1371/journal.pone.0166052

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Extensively drug-resistant tuberculosis
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