ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Bin Ma; Doug Marcotte; Murugan Paramasivam; Klaus Michelsen; Ti Wang; Andrea Bertolotti-Ciarlet; John Howard Jones; Ben Moree; Margaret Butko; Joshua Salafsky; Xin Sun; Timothy McKee; Laura F. Silvian

doi:10.1371/journal.pone.0165983

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Open Access

Peer-reviewed

Research Article

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Bin Ma,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Doug Marcotte,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Murugan Paramasivam,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Klaus Michelsen,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Ti Wang,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Andrea Bertolotti-Ciarlet,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
John Howard Jones,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Ben Moree,

Affiliation Biodesy Inc., South San Francisco, CA, 94080, United States of America
⨯
Margaret Butko,

Affiliation Biodesy Inc., South San Francisco, CA, 94080, United States of America
⨯
Joshua Salafsky,

Affiliation Biodesy Inc., South San Francisco, CA, 94080, United States of America
⨯
Xin Sun,

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Timothy McKee,

Current address: Rodin Therapeutics, 400 Technology Square, Cambridge, MA, 02139, United States of America

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America
⨯
Laura F. Silvian

* E-mail: laura.silvian@biogen.com

Affiliation Drug Discovery, Biogen Inc., Cambridge, MA, 02142, United States of America

http://orcid.org/0000-0002-5299-5201

⨯

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Bin Ma,
Doug Marcotte,
Murugan Paramasivam,
Klaus Michelsen,
Ti Wang,
Andrea Bertolotti-Ciarlet,
John Howard Jones,
Ben Moree,
Margaret Butko,
Joshua Salafsky

Published: November 10, 2016
https://doi.org/10.1371/journal.pone.0165983

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