Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages

Jeffrey A. Deiuliis; Rafay Syed; Dheeraj Duggineni; Jessica Rutsky; Palanivel Rengasamy; Jie Zhang; Kun Huang; Bradley Needleman; Dean Mikami; Kyle Perry; Jeffrey Hazey; Sanjay Rajagopalan

doi:10.1371/journal.pone.0165962

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Open Access

Peer-reviewed

Research Article

Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages

Jeffrey A. Deiuliis ,

* E-mail: jeffrey.deiuliis@gmail.com

Affiliations Department of Medicine, Division of Cardiovascular Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, United States of America, Dorothy Davis Heart and Lung Institute, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America

http://orcid.org/0000-0002-5665-8894

⨯
Rafay Syed,

Affiliation Department of Medicine, Division of Cardiovascular Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, United States of America
⨯
Dheeraj Duggineni,

Affiliation Dorothy Davis Heart and Lung Institute, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Jessica Rutsky,

Affiliation Dorothy Davis Heart and Lung Institute, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Palanivel Rengasamy,

Affiliation Department of Medicine, Division of Cardiovascular Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, United States of America
⨯
Jie Zhang,

Affiliation Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Kun Huang,

Affiliation Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Bradley Needleman,

Affiliation Department of Surgery, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Dean Mikami,

Affiliation Department of Surgery, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Kyle Perry,

Affiliation Department of Surgery, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Jeffrey Hazey,

Affiliation Department of Surgery, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯
Sanjay Rajagopalan

Affiliations Department of Medicine, Division of Cardiovascular Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, United States of America, Dorothy Davis Heart and Lung Institute, The Ohio State University College of Medicine, Columbus, OH 43210, United States of America
⨯

Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages

Jeffrey A. Deiuliis,
Rafay Syed,
Dheeraj Duggineni,
Jessica Rutsky,
Palanivel Rengasamy,
Jie Zhang,
Kun Huang,
Bradley Needleman,
Dean Mikami,
Kyle Perry

Published: November 3, 2016
https://doi.org/10.1371/journal.pone.0165962

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Macrophages
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MicroRNAs
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Obesity
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Toll-like receptors
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Inflammation
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Insulin
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Insulin resistance
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Inflammatory diseases
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