Transcriptional Activation of Pericentromeric Satellite Repeats and Disruption of Centromeric Clustering upon Proteasome Inhibition

Theona Natisvili; Cihangir Yandim; Raquel Silva; Giulia Emanuelli; Felix Krueger; Sathiji Nageshwaran; Richard Festenstein

doi:10.1371/journal.pone.0165873

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Peer-reviewed

Research Article

Transcriptional Activation of Pericentromeric Satellite Repeats and Disruption of Centromeric Clustering upon Proteasome Inhibition

Theona Natisvili,

Affiliation Gene Control Mechanisms and Disease Group, Department of Medicine, Division of Brain Sciences and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Cihangir Yandim,

Current address: The Institute of Cancer Research, 15 Cotswold Road, Sutton, London, United Kingdom

Affiliation Gene Control Mechanisms and Disease Group, Department of Medicine, Division of Brain Sciences and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Raquel Silva,

Current address: Institute of Ophthalmology, University College London, 11–43 Bath Street, London, United Kingdom

Affiliation Gene Control Mechanisms and Disease Group, Department of Medicine, Division of Brain Sciences and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Giulia Emanuelli,

Current address: Cardiovascular division, James Black Centre, King’s College London, Denmark Hill campus, London, United Kingdom

Affiliation Gene Control Mechanisms and Disease Group, Department of Medicine, Division of Brain Sciences and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Felix Krueger,

Affiliation Bioinformatics Group, Babraham Institute, Cambridge, United Kingdom
⨯
Sathiji Nageshwaran,

Affiliation Gene Control Mechanisms and Disease Group, Department of Medicine, Division of Brain Sciences and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Richard Festenstein

* E-mail: r.festenstein@imperial.ac.uk

Affiliation Gene Control Mechanisms and Disease Group, Department of Medicine, Division of Brain Sciences and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯

Transcriptional Activation of Pericentromeric Satellite Repeats and Disruption of Centromeric Clustering upon Proteasome Inhibition

Theona Natisvili,
Cihangir Yandim,
Raquel Silva,
Giulia Emanuelli,
Felix Krueger,
Sathiji Nageshwaran,
Richard Festenstein

Published: November 2, 2016
https://doi.org/10.1371/journal.pone.0165873

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Proteasomes
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Heterochromatin
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Transcriptional control
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Cell cycle and cell division
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DNA transcription
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Chromatin
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Cell staining
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