Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

Zbynek Heger; Miguel Angel Merlos Rodrigo; Petr Michalek; Hana Polanska; Michal Masarik; Vitezslav Vit; Mariana Plevova; Dalibor Pacik; Tomas Eckschlager; Marie Stiborova; Vojtech Adam

doi:10.1371/journal.pone.0165830

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Open Access

Peer-reviewed

Research Article

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

Zbynek Heger,

Affiliations Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00, Brno, Czech Republic, Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, CZ-612 00, Czech Republic
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Miguel Angel Merlos Rodrigo,

Affiliations Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00, Brno, Czech Republic, Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, CZ-612 00, Czech Republic
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Petr Michalek,

Affiliations Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00, Brno, Czech Republic, Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, CZ-612 00, Czech Republic
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Hana Polanska,

Affiliation Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, CZ-625 00, Czech Republic
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Michal Masarik,

Affiliations Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, CZ-612 00, Czech Republic, Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, CZ-625 00, Czech Republic
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Vitezslav Vit,

Affiliation Department of Urology, University Hospital Brno, Jihlavska 20, Brno, CZ-625 00, Czech Republic
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Mariana Plevova,

Affiliation Department of Urology, University Hospital Brno, Jihlavska 20, Brno, CZ-625 00, Czech Republic
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Dalibor Pacik,

Affiliation Department of Urology, University Hospital Brno, Jihlavska 20, Brno, CZ-625 00, Czech Republic
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Tomas Eckschlager,

Affiliation Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University, and University Hospital Motol, V Uvalu 84, CZ-150 06, Prague 5, Czech Republic
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Marie Stiborova,

Affiliation Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128 40, Prague 2, Czech Republic
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Vojtech Adam

* E-mail: vojtech.adam@mendelu.cz

Affiliations Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00, Brno, Czech Republic, Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, CZ-612 00, Czech Republic

http://orcid.org/0000-0002-8527-286X

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Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

Zbynek Heger,
Miguel Angel Merlos Rodrigo,
Petr Michalek,
Hana Polanska,
Michal Masarik,
Vitezslav Vit,
Mariana Plevova,
Dalibor Pacik,
Tomas Eckschlager,
Marie Stiborova

Published: November 8, 2016
https://doi.org/10.1371/journal.pone.0165830

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Cancer treatment
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Prostate cancer
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Cancers and neoplasms
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Gene expression
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Cell cycle and cell division
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