Development of PET Imaging to Visualize Activated Macrophages Accumulated in the Transplanted iPSc-Derived Cardiac Myocytes of Allogeneic Origin for Detecting the Immune Rejection of Allogeneic Cell Transplants in Mice

Noriyuki Kashiyama; Shigeru Miyagawa; Satsuki Fukushima; Takuji Kawamura; Ai Kawamura; Shohei Yoshida; Akima Harada; Tadashi Watabe; Yasukazu Kanai; Koichi Toda; Jun Hatazawa; Yoshiki Sawa

doi:10.1371/journal.pone.0165748

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Open Access

Peer-reviewed

Research Article

Development of PET Imaging to Visualize Activated Macrophages Accumulated in the Transplanted iPSc-Derived Cardiac Myocytes of Allogeneic Origin for Detecting the Immune Rejection of Allogeneic Cell Transplants in Mice

Noriyuki Kashiyama,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Shigeru Miyagawa,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Satsuki Fukushima,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Takuji Kawamura,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Ai Kawamura,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Shohei Yoshida,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Akima Harada,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Tadashi Watabe,

Affiliations Dept. Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan, PET Molecular Imaging Center, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Yasukazu Kanai,

Affiliation Dept. Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Koichi Toda,

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Jun Hatazawa,

Affiliations Dept. Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan, PET Molecular Imaging Center, Osaka University Graduate School of Medicine, Osaka, Japan, Immunology Frontier Research Center, Osaka University, Osaka, Japan
⨯
Yoshiki Sawa

* E-mail: sawa-p@surg1.med.osaka-u.ac.jp

Affiliation Dept. Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
⨯

Development of PET Imaging to Visualize Activated Macrophages Accumulated in the Transplanted iPSc-Derived Cardiac Myocytes of Allogeneic Origin for Detecting the Immune Rejection of Allogeneic Cell Transplants in Mice

Noriyuki Kashiyama,
Shigeru Miyagawa,
Satsuki Fukushima,
Takuji Kawamura,
Ai Kawamura,
Shohei Yoshida,
Akima Harada,
Tadashi Watabe,
Yasukazu Kanai,
Koichi Toda

Published: December 8, 2016
https://doi.org/10.1371/journal.pone.0165748

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Cardiac transplantation
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Positron emission tomography
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Macrophages
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Cell transplantation
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Transplant rejection
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