The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective

Ying Hong Li; Pan Pan Wang; Xiao Xu Li; Chun Yan Yu; Hong Yang; Jin Zhou; Wei Wei Xue; Jun Tan; Feng Zhu

doi:10.1371/journal.pone.0165737

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Peer-reviewed

Research Article

The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective

Ying Hong Li ,

Contributed equally to this work with: Ying Hong Li, Pan Pan Wang, Xiao Xu Li

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Pan Pan Wang ,

Contributed equally to this work with: Ying Hong Li, Pan Pan Wang, Xiao Xu Li

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Xiao Xu Li ,

Contributed equally to this work with: Ying Hong Li, Pan Pan Wang, Xiao Xu Li

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Chun Yan Yu,

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Hong Yang,

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Jin Zhou,

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Wei Wei Xue,

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯
Jun Tan,

Affiliation Institute of Bioinformation, Chongqing University of Posts and Telecommunications, Chongqing, China
⨯
Feng Zhu

* E-mail: zhufeng@cqu.edu.cn

Affiliation Innovative Drug Research and Bioinformatics Group, Innovative Drug Research Centre and School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
⨯

The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective

Ying Hong Li,
Pan Pan Wang,
Xiao Xu Li,
Chun Yan Yu,
Hong Yang,
Jin Zhou,
Wei Wei Xue,
Jun Tan,
Feng Zhu

Published: November 9, 2016
https://doi.org/10.1371/journal.pone.0165737

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