Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells

Bin Tang; Kun Wang; Yin-ping Jia; Pan Zhu; Yao Fang; Zhu-jun Zhang; Xu-hu Mao; Qian Li; Dong-Zhu Zeng

doi:10.1371/journal.pone.0165701

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Open Access

Peer-reviewed

Research Article

Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells

Bin Tang ,

Contributed equally to this work with: Bin Tang, Kun Wang

Affiliations Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China, Emei Sanatorium of PLA Rocket Force, Emeishan, China
⨯
Kun Wang ,

Contributed equally to this work with: Bin Tang, Kun Wang

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Yin-ping Jia,

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Pan Zhu,

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Yao Fang,

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Zhu-jun Zhang,

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Xu-hu Mao,

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Qian Li ,

* E-mail: zdz1140@163.com (DZZ); liqianjane@163.com (QL)

Affiliation Department of Clinical Microbiology and Immunology, Southwest Hospital & College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
⨯
Dong-Zhu Zeng

* E-mail: zdz1140@163.com (DZZ); liqianjane@163.com (QL)

Affiliation Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯

Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells

Bin Tang,
Kun Wang,
Yin-ping Jia,
Pan Zhu,
Yao Fang,
Zhu-jun Zhang,
Xu-hu Mao,
Qian Li,
Dong-Zhu Zeng

Published: November 9, 2016
https://doi.org/10.1371/journal.pone.0165701

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Caco-2 cells
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Autophagic cell death
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