CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice

Xuguang Chen; Yunyue Wang; David Nelson; Sara Tian; Erin Mulvey; Bhumi Patel; Ilaria Conti; Juan Jaen; Barrett J. Rollins

doi:10.1371/journal.pone.0165595

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Open Access

Peer-reviewed

Research Article

CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice

Xuguang Chen,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America, Harvard Medical School, Boston, Massachusetts 02115, United States of America
⨯
Yunyue Wang,

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America, Harvard Medical School, Boston, Massachusetts 02115, United States of America
⨯
David Nelson,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America
⨯
Sara Tian,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America
⨯
Erin Mulvey,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America
⨯
Bhumi Patel,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America
⨯
Ilaria Conti,

Current address: Eli Lilly and Co., Indianapolis, IN 46285, United States of America

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America
⨯
Juan Jaen,

Current address: Arcus Biosciences, Inc., Hayward, CA 94545, United States of America

Affiliation ChemoCentryx, Inc., Mountain View, California 94043, United States of America
⨯
Barrett J. Rollins

* E-mail: Barrett_Rollins@dfci.harvard.edu

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02215, United States of America, Harvard Medical School, Boston, Massachusetts 02115, United States of America
⨯

CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice

Xuguang Chen,
Yunyue Wang,
David Nelson,
Sara Tian,
Erin Mulvey,
Bhumi Patel,
Ilaria Conti,
Juan Jaen,
Barrett J. Rollins

Published: November 7, 2016
https://doi.org/10.1371/journal.pone.0165595

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