Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury

• Masahiro Tokuno ,

  Contributed equally to this work with: Masahiro Tokuno, Kazuaki Taguchi

  Affiliation Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan

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• Kazuaki Taguchi ,

  Contributed equally to this work with: Masahiro Tokuno, Kazuaki Taguchi

  Affiliation Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan

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• Keishi Yamasaki,

  Affiliations Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan, DDS Research Institute, Sojo University, Kumamoto, Japan

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• Hiromi Sakai,

  Affiliation Department of Chemistry, Nara Medical University, Nara, Japan

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• Masaki Otagiri

  * E-mail: otagirim@ph.sojo-u.ac.jp

  Affiliations Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan, DDS Research Institute, Sojo University, Kumamoto, Japan

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