Identification of an Allosteric Binding Site on Human Lysosomal Alpha-Galactosidase Opens the Way to New Pharmacological Chaperones for Fabry Disease

• Valentina Citro ,

  Contributed equally to this work with: Valentina Citro, Jorge Peña-García

  Affiliation Dipartimento di Biologia, Università Federico II, Napoli, 80126, Italy

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• Jorge Peña-García ,

  Contributed equally to this work with: Valentina Citro, Jorge Peña-García

  Affiliation Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica San Antonio de Murcia (UCAM), Spain

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• Helena den-Haan,

  Affiliation Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica San Antonio de Murcia (UCAM), Spain

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• Horacio Pérez-Sánchez ,

  * E-mail: cubellis@unina.it (MVC); hperez@ucam.edu (HPS)

  Affiliation Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica San Antonio de Murcia (UCAM), Spain

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• Rosita Del Prete,

  Affiliation Dipartimento di Biologia, Università Federico II, Napoli, 80126, Italy

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• Ludovica Liguori,

  Affiliations Dipartimento di Biologia, Università Federico II, Napoli, 80126, Italy, Istituto di Chimica Biomolecolare–CNR, Pozzuoli, 80078, Italy

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• Chiara Cimmaruta,

  Affiliations Dipartimento di Biologia, Università Federico II, Napoli, 80126, Italy, Istituto di Chimica Biomolecolare–CNR, Pozzuoli, 80078, Italy

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• Jan Lukas,

  Affiliation Albrecht-Kossel-Institute for Neuroregeneration, Medical University Rostock, Rostock, Germany

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• Maria Vittoria Cubellis ,

  * E-mail: cubellis@unina.it (MVC); hperez@ucam.edu (HPS)

  Affiliation Dipartimento di Biologia, Università Federico II, Napoli, 80126, Italy

  http://orcid.org/0000-0001-6147-6553

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• Giuseppina Andreotti

  Affiliation Istituto di Chimica Biomolecolare–CNR, Pozzuoli, 80078, Italy

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