Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing

Dae Woo Park; Andrea Sebastiani; Choon Hwai Yap; Marc A. Simon; Kang Kim

doi:10.1371/journal.pone.0165320

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Research Article

Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing

Dae Woo Park,

Affiliation Center for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Andrea Sebastiani,

Affiliation Heart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, United States of America
⨯
Choon Hwai Yap,

Affiliation Department of Biomedical Engineering, National University of Singapore, Singapore
⨯
Marc A. Simon,

Affiliations Heart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, United States of America, Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, Pennsylvania, United States of America, McGowan Institute for Regenerative Medicine, University of Pittsburgh and UPMC, Pittsburgh, Pennsylvania, United States of America, Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Kang Kim

* E-mail: kangkim@upmc.edu

Affiliations Center for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Heart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, United States of America, Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, Pennsylvania, United States of America, McGowan Institute for Regenerative Medicine, University of Pittsburgh and UPMC, Pittsburgh, Pennsylvania, United States of America, Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing

Dae Woo Park,
Andrea Sebastiani,
Choon Hwai Yap,
Marc A. Simon,
Kang Kim

Published: October 25, 2016
https://doi.org/10.1371/journal.pone.0165320

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