Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

Tomohiro Yamashita; Shota Yamamoto; Jiaming Zhang; Miho Kometani; Daisuke Tomiyama; Keita Kohno; Hidetoshi Tozaki-Saitoh; Kazuhide Inoue; Makoto Tsuda

doi:10.1371/journal.pone.0165189

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Peer-reviewed

Research Article

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

Tomohiro Yamashita,

Affiliation Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
⨯
Shota Yamamoto,

Affiliation Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
⨯
Jiaming Zhang,

Affiliation Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
⨯
Miho Kometani,

Affiliation Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
⨯
Daisuke Tomiyama,

Affiliation Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
⨯
Keita Kohno,

Affiliation Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
⨯
Hidetoshi Tozaki-Saitoh,

Affiliations Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
⨯
Kazuhide Inoue ,

* E-mail: tsuda@phar.kyushu-u.ac.jp (MT); inoue@phar.kyushu-u.ac.jp (KI)

Affiliation Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
⨯
Makoto Tsuda

* E-mail: tsuda@phar.kyushu-u.ac.jp (MT); inoue@phar.kyushu-u.ac.jp (KI)

Affiliations Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
⨯

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

Tomohiro Yamashita,
Shota Yamamoto,
Jiaming Zhang,
Miho Kometani,
Daisuke Tomiyama,
Keita Kohno,
Hidetoshi Tozaki-Saitoh,
Kazuhide Inoue,
Makoto Tsuda

Published: October 21, 2016
https://doi.org/10.1371/journal.pone.0165189

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