Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

Cristina Puy; Erik I. Tucker; Ivan S. Ivanov; David Gailani; Stephanie A. Smith; James H. Morrissey; András Gruber; Owen J. T. McCarty

doi:10.1371/journal.pone.0165172

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Peer-reviewed

Research Article

Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

Cristina Puy ,

* E-mail: puygarci@ohsu.edu

Affiliations Departments of Biomedical Engineering Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of America
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Erik I. Tucker,

Affiliations Departments of Biomedical Engineering Oregon Health & Science University, Portland, Oregon, United States of America, Aronora, Inc, Portland, Oregon, United States of America
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Ivan S. Ivanov,

Affiliation Departments of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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David Gailani,

Affiliation Departments of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Stephanie A. Smith,

Affiliation Biochemistry Department, University of Illinois, Urbana, Illinois, United States of America
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James H. Morrissey,

Affiliation Biochemistry Department, University of Illinois, Urbana, Illinois, United States of America
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András Gruber,

Affiliations Departments of Biomedical Engineering Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of America, Aronora, Inc, Portland, Oregon, United States of America
⨯
Owen J. T. McCarty

Affiliations Departments of Biomedical Engineering Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of America, Department of Cell, Developmental and Cancer Biology Oregon Health & Science University, Portland, Oregon, United States of America
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Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

Cristina Puy,
Erik I. Tucker,
Ivan S. Ivanov,
David Gailani,
Stephanie A. Smith,
James H. Morrissey,
András Gruber,
Owen J. T. McCarty

Published: October 20, 2016
https://doi.org/10.1371/journal.pone.0165172

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Platelet activation
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