MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme

• Alexandra Sufit,

  Affiliation University of Colorado Anschutz Medical Campus, 12800 E 19th Avenue, Aurora, CO, 80045, United States of America

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• Alisa B. Lee-Sherick,

  Affiliations University of Colorado Anschutz Medical Campus, 12800 E 19th Avenue, Aurora, CO, 80045, United States of America, Children’s Hospital Colorado, 13123 E. 16th Ave, Aurora, CO, 80045, United States of America

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• Deborah DeRyckere,

  Affiliation Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, 30322, United States of America

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• Manali Rupji,

  Affiliation Winship Cancer Institute, Emory University, Atlanta, GA, 30333, United States of America

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• Bhakti Dwivedi,

  Affiliation Winship Cancer Institute, Emory University, Atlanta, GA, 30333, United States of America

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• Marileila Varella-Garcia,

  Affiliation University of Colorado Anschutz Medical Campus, 12800 E 19th Avenue, Aurora, CO, 80045, United States of America

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• Angela M. Pierce,

  Affiliation University of Colorado Anschutz Medical Campus, 12800 E 19th Avenue, Aurora, CO, 80045, United States of America

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• Jeanne Kowalski,

  Affiliations Winship Cancer Institute, Emory University, Atlanta, GA, 30333, United States of America, Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, 30333, United States of America

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• Xiaodong Wang,

  Affiliation Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

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• Stephen V. Frye,

  Affiliations Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, Unites States of America

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• H. Shelton Earp,

  Affiliation Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, Unites States of America

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• Amy K. Keating ,

  Contributed equally to this work with: Amy K. Keating, Douglas K. Graham

  * E-mail: Amy.Keating@ucdenver.edu (AKK); Douglas.Graham@choa.org (DKG)

  Affiliations University of Colorado Anschutz Medical Campus, 12800 E 19th Avenue, Aurora, CO, 80045, United States of America, Children’s Hospital Colorado, 13123 E. 16th Ave, Aurora, CO, 80045, United States of America

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• Douglas K. Graham

  Contributed equally to this work with: Amy K. Keating, Douglas K. Graham

  * E-mail: Amy.Keating@ucdenver.edu (AKK); Douglas.Graham@choa.org (DKG)

  Affiliations Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, 30322, United States of America, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

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