Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ

Li Fang; Qiong Chen; Keren Shi; Xi Li; Qiucheng Shi; Fang He; Jiancang Zhou; Yunsong Yu; Xiaoting Hua

doi:10.1371/journal.pone.0165019

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Open Access

Peer-reviewed

Research Article

Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ

Li Fang,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Qiong Chen,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Keren Shi,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Xi Li,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Qiucheng Shi,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Fang He,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Jiancang Zhou,

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Yunsong Yu ,

* E-mail: XiaotingHua@zju.edu.cn (XH); yvys119@163.com (YY)

Affiliations Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
⨯
Xiaoting Hua

* E-mail: XiaotingHua@zju.edu.cn (XH); yvys119@163.com (YY)

Affiliation Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China

http://orcid.org/0000-0001-8215-916X

⨯

Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ

Li Fang,
Qiong Chen,
Keren Shi,
Xi Li,
Qiucheng Shi,
Fang He,
Jiancang Zhou,
Yunsong Yu,
Xiaoting Hua

Published: October 20, 2016
https://doi.org/10.1371/journal.pone.0165019

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Point mutation
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