Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation

Kishore Polireddy; Ruochen Dong; Peter R. McDonald; Tao Wang; Brendan Luke; Ping Chen; Melinda Broward; Anuradha Roy; Qi Chen

doi:10.1371/journal.pone.0164811

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Peer-reviewed

Research Article

Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation

Kishore Polireddy,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas, United States of America
⨯
Ruochen Dong,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas, United States of America
⨯
Peter R. McDonald,

Affiliation High-Throughput Screening Core Facility, Structural Biology Center, University of Kansas, Lawrence, Kansas, United States of America
⨯
Tao Wang,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas, United States of America
⨯
Brendan Luke,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas, United States of America
⨯
Ping Chen,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas, United States of America
⨯
Melinda Broward,

Affiliation High-Throughput Screening Core Facility, Structural Biology Center, University of Kansas, Lawrence, Kansas, United States of America
⨯
Anuradha Roy,

Affiliation High-Throughput Screening Core Facility, Structural Biology Center, University of Kansas, Lawrence, Kansas, United States of America
⨯
Qi Chen

* E-mail: qchen@kumc.edu

Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas, United States of America
⨯

Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation

Kishore Polireddy,
Ruochen Dong,
Peter R. McDonald,
Tao Wang,
Brendan Luke,
Ping Chen,
Melinda Broward,
Anuradha Roy,
Qi Chen

Published: October 20, 2016
https://doi.org/10.1371/journal.pone.0164811

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