Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice

Yanna Si; Yuan Zhang; Liu Han; Lihai Chen; Yajie Xu; Fan Sun; Muhuo Ji; Jianjun Yang; Hongguang Bao

doi:10.1371/journal.pone.0164763

Loading metrics

Open Access

Peer-reviewed

Research Article

Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice

Yanna Si,

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yuan Zhang,

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Liu Han,

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Lihai Chen,

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yajie Xu,

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Fan Sun,

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Muhuo Ji,

Affiliation Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Anesthesiology, College of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, China
⨯
Jianjun Yang,

Affiliation Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China; Jiangsu Province Key Laboratory of Anesthesiology, College of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, China
⨯
Hongguang Bao

* E-mail: hongguang_bao@hotmail.com

Affiliation Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
⨯

Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice

Yanna Si,
Yuan Zhang,
Liu Han,
Lihai Chen,
Yajie Xu,
Fan Sun,
Muhuo Ji,
Jianjun Yang,
Hongguang Bao

Published: October 21, 2016
https://doi.org/10.1371/journal.pone.0164763

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hippocampus
Is the Subject Area "Hippocampus" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Cognitive impairment
Is the Subject Area "Cognitive impairment" applicable to this article?

Thanks for your feedback.
Anesthesia
Is the Subject Area "Anesthesia" applicable to this article?

Thanks for your feedback.
Learning and memory
Is the Subject Area "Learning and memory" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Inhalation
Is the Subject Area "Inhalation" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.