Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity

Jose Luis Muñoz-Bravo; Alvaro Flores-Martínez; Griselda Herrero-Martin; Sapna Puri; Makoto Mark Taketo; Anabel Rojas; Matthias Hebrok; David A. Cano

doi:10.1371/journal.pone.0164714

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Open Access

Peer-reviewed

Research Article

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity

Jose Luis Muñoz-Bravo ,

Contributed equally to this work with: Jose Luis Muñoz-Bravo, Alvaro Flores-Martínez

Affiliations Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, Spain, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Sevilla, Spain
⨯
Alvaro Flores-Martínez ,

Contributed equally to this work with: Jose Luis Muñoz-Bravo, Alvaro Flores-Martínez

Affiliations Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, Spain, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Sevilla, Spain
⨯
Griselda Herrero-Martin,

Affiliations Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, Spain, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Sevilla, Spain
⨯
Sapna Puri,

Affiliation Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, United States of America
⨯
Makoto Mark Taketo,

Affiliation Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Anabel Rojas,

Affiliations Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Sevilla, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain
⨯
Matthias Hebrok,

Affiliation Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, United States of America
⨯
David A. Cano

* E-mail: dcano-ibis@us.es

Affiliations Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, Spain, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Sevilla, Spain
⨯

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity

Jose Luis Muñoz-Bravo,
Alvaro Flores-Martínez,
Griselda Herrero-Martin,
Sapna Puri,
Makoto Mark Taketo,
Anabel Rojas,
Matthias Hebrok,
David A. Cano

Published: October 13, 2016
https://doi.org/10.1371/journal.pone.0164714

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Pancreas
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Epithelium
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Gastrointestinal tract
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Stomach
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Wnt signaling cascade
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Hedgehog signaling
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Duodenum
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