Mechanistic Insights into Archaeal and Human Argonaute Substrate Binding and Cleavage Properties

Open Access

Peer-reviewed

Research Article

Sarah Willkomm,

Current address: Department of Biochemistry, Genetics and Microbiology, Institute of Microbiology- Archaea Centre, University of Regensburg, Regensburg, 93053, Germany

Affiliation Institute of Molecular Medicine, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck, Lübeck, 23538, Germany
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Adrian Zander,

Affiliation Department of Biochemistry, Genetics and Microbiology, Institute of Microbiology- Archaea Centre, University of Regensburg, Regensburg, 93053, Germany
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Dina Grohmann,

Affiliation Department of Biochemistry, Genetics and Microbiology, Institute of Microbiology- Archaea Centre, University of Regensburg, Regensburg, 93053, Germany
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Tobias Restle

* E-mail: restle@imm.uni-luebeck.de

Affiliation Institute of Molecular Medicine, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck, Lübeck, 23538, Germany
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Small interfering RNA
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DNA cleavage
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Chemical dissociation
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Nucleic acids
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Phase determination
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Crystallization seeding
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Binding analysis
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RNA analysis
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