Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker; Daniel Dairaghi; Lisa Seitz; Manmohan Leleti; Yu Wang; Linda Ertl; Trageen Baumgart; Sarah Shugarts; Lisa Lohr; Ton Dang; Shichang Miao; Yibin Zeng; Pingchen Fan; Penglie Zhang; Daniel Johnson; Jay Powers; Juan Jaen; Israel Charo; Thomas J. Schall

doi:10.1371/journal.pone.0164646

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Research Article

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker ,

* E-mail: pbekker@chemocentryx.com

Affiliation Department of Medical and Clinical Affairs, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Daniel Dairaghi,

Affiliation Department of Biology, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Lisa Seitz,

Affiliation Department of Biology, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Manmohan Leleti,

Affiliation Department of Chemistry, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Yu Wang,

Affiliation Department of Biology, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Linda Ertl,

Affiliation Department of Biology, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Trageen Baumgart,

Affiliation Department of Biology, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Sarah Shugarts,

Affiliation Department of Drug Metabolism and Pharmacokinetics, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Lisa Lohr,

Affiliation Department of Drug Metabolism and Pharmacokinetics, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Ton Dang,

Affiliation Department of Drug Metabolism and Pharmacokinetics, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Shichang Miao,

Affiliation Department of Drug Metabolism and Pharmacokinetics, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Yibin Zeng,

Affiliation Department of Chemistry, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Pingchen Fan,

Affiliation Department of Chemistry, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Penglie Zhang,

Affiliation Department of Chemistry, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Daniel Johnson,

Affiliation Department of Medical and Clinical Affairs, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Jay Powers,

Affiliation Department of Chemistry, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Juan Jaen,

Affiliation Department of Discovery and Research, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
Israel Charo,

Affiliation Department of Discovery and Research, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
[ ... ],
Thomas J. Schall

Affiliation Department of Discovery and Research, ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, California, United States of America
⨯
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Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker,
Daniel Dairaghi,
Lisa Seitz,
Manmohan Leleti,
Yu Wang,
Linda Ertl,
Trageen Baumgart,
Sarah Shugarts,
Lisa Lohr,
Ton Dang

Published: October 21, 2016
https://doi.org/10.1371/journal.pone.0164646

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