Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Wei Jiang; Essel Dulaimi; Karthik Devarajan; Theodore Parsons; Qiong Wang; Lili Liao; Eun-Ah Cho; Raymond O'Neill; Charalambos Solomides; Stephen C. Peiper; Joseph R. Testa; Robert Uzzo; Haifeng Yang

doi:10.1371/journal.pone.0164554

Loading metrics

Open Access

Peer-reviewed

Research Article

Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Wei Jiang ,

Contributed equally to this work with: Wei Jiang, Essel Dulaimi

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Essel Dulaimi ,

Contributed equally to this work with: Wei Jiang, Essel Dulaimi

Affiliation Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Karthik Devarajan,

Affiliation Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Theodore Parsons,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Qiong Wang,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Lili Liao,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Eun-Ah Cho,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Raymond O'Neill,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Charalambos Solomides,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Stephen C. Peiper,

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Joseph R. Testa,

Affiliation Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Robert Uzzo,

Affiliations Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Haifeng Yang

* E-mail: haifeng.yang@jefferson.edu

Affiliation Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯

Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma

Wei Jiang,
Essel Dulaimi,
Karthik Devarajan,
Theodore Parsons,
Qiong Wang,
Lili Liao,
Eun-Ah Cho,
Raymond O'Neill,
Charalambos Solomides,
Stephen C. Peiper

Published: October 20, 2016
https://doi.org/10.1371/journal.pone.0164554

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Renal cancer
Is the Subject Area "Renal cancer" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Non-small cell lung cancer
Is the Subject Area "Non-small cell lung cancer" applicable to this article?

Thanks for your feedback.
Immunohistochemistry techniques
Is the Subject Area "Immunohistochemistry techniques" applicable to this article?

Thanks for your feedback.
Gastrointestinal cancers
Is the Subject Area "Gastrointestinal cancers" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.