A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Brandi M. Baughman; Huanchen Wang; Yi An; Dmitri Kireev; Michael A. Stashko; Henning J. Jessen; Kenneth H. Pearce; Stephen V. Frye; Stephen B. Shears

doi:10.1371/journal.pone.0164378

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Open Access

Peer-reviewed

Research Article

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Brandi M. Baughman,

Affiliations Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, North Carolina, United States of America

http://orcid.org/0000-0002-8861-1345

⨯
Huanchen Wang,

Affiliation Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Yi An,

Affiliation Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Dmitri Kireev,

Affiliation Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Michael A. Stashko,

Affiliation Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Henning J. Jessen,

Affiliation Institute of Organic Chemistry, Albert-Ludwigs-University of Freiburg, Freiburg 79104, Germany
⨯
Kenneth H. Pearce,

Affiliation Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Stephen V. Frye,

Affiliation Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Stephen B. Shears

* E-mail: brandi.baughman@nih.gov

Affiliation Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Brandi M. Baughman,
Huanchen Wang,
Yi An,
Dmitri Kireev,
Michael A. Stashko,
Henning J. Jessen,
Kenneth H. Pearce,
Stephen V. Frye,
Stephen B. Shears

Published: October 13, 2016
https://doi.org/10.1371/journal.pone.0164378

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Library screening
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Phosphates
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Nucleotides
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Protein kinases
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Signal inhibition
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Binding analysis
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Enzymes
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Kinase inhibitors
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