The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair

Ilenia Pellarin; Laura Arnoldo; Silvia Costantini; Silvia Pegoraro; Gloria Ros; Carlotta Penzo; Gianluca Triolo; Francesca Demarchi; Riccardo Sgarra; Alessandro Vindigni; Guidalberto Manfioletti

doi:10.1371/journal.pone.0164258

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Open Access

Peer-reviewed

Research Article

The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair

Ilenia Pellarin ,

Contributed equally to this work with: Ilenia Pellarin, Laura Arnoldo

Current address: Centro di Riferimento Oncologico (CRO), Aviano, Italy

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Laura Arnoldo ,

Contributed equally to this work with: Ilenia Pellarin, Laura Arnoldo

Current address: United Word College of the Adriatic, Duino Aurisina, Italy

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Silvia Costantini,

Current address: Azienda Ospedaliero-Universitaria “S. Maria della Misericordia”, Udine, Italy

Affiliation International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
⨯
Silvia Pegoraro,

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Gloria Ros,

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Carlotta Penzo,

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Gianluca Triolo,

Affiliation International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
⨯
Francesca Demarchi,

Affiliation Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (LNCIB), AREA Science Park, Trieste, Italy
⨯
Riccardo Sgarra,

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Alessandro Vindigni,

Affiliation Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
⨯
Guidalberto Manfioletti

* E-mail: manfiole@units.it

Affiliation Department of Life Sciences, University of Trieste, Trieste, Italy
⨯

The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair

Ilenia Pellarin,
Laura Arnoldo,
Silvia Costantini,
Silvia Pegoraro,
Gloria Ros,
Carlotta Penzo,
Gianluca Triolo,
Francesca Demarchi,
Riccardo Sgarra,
Alessandro Vindigni

Published: October 10, 2016
https://doi.org/10.1371/journal.pone.0164258

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Phosphorylation
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Ligases
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DNA damage
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DNA repair
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Breast cancer
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Histones
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Ligation assay
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Non-homologous end joining
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