Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

František Liška; Renata Peterková; Miroslav Peterka; Vladimír Landa; Václav Zídek; Petr Mlejnek; Jan Šilhavý; Miroslava Šimáková; Vladimír Křen; Colby G. Starker; Daniel F. Voytas; Zsuzsanna Izsvák; Michal Pravenec

doi:10.1371/journal.pone.0164206

Loading metrics

Open Access

Peer-reviewed

Research Article

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

František Liška,

Affiliation Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University in Prague, Prague, Czech Republic
⨯
Renata Peterková,

Affiliation Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
⨯
Miroslav Peterka,

Affiliation Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
⨯
Vladimír Landa,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Václav Zídek,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Petr Mlejnek,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Jan Šilhavý,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Miroslava Šimáková,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Vladimír Křen,

Affiliations Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University in Prague, Prague, Czech Republic, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Colby G. Starker,

Affiliation University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Daniel F. Voytas,

Affiliation University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Zsuzsanna Izsvák,

Affiliation Max Delbrück Center for Molecular Medicine, Berlin, Germany
⨯
Michal Pravenec

* E-mail: pravenec@biomed.cas.cz

Affiliations Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University in Prague, Prague, Czech Republic, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
⨯

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats

František Liška,
Renata Peterková,
Miroslav Peterka,
Vladimír Landa,
Václav Zídek,
Petr Mlejnek,
Jan Šilhavý,
Miroslava Šimáková,
Vladimír Křen,
Colby G. Starker

Published: October 11, 2016
https://doi.org/10.1371/journal.pone.0164206

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Tails
Is the Subject Area "Tails" applicable to this article?

Thanks for your feedback.
Homozygosity
Is the Subject Area "Homozygosity" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Fetuses
Is the Subject Area "Fetuses" applicable to this article?

Thanks for your feedback.
Heterozygosity
Is the Subject Area "Heterozygosity" applicable to this article?

Thanks for your feedback.
Ureter
Is the Subject Area "Ureter" applicable to this article?

Thanks for your feedback.
Renal system
Is the Subject Area "Renal system" applicable to this article?

Thanks for your feedback.
Vertebrae
Is the Subject Area "Vertebrae" applicable to this article?

Thanks for your feedback.