Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation

Michela Asperti; Tanja Stuemler; Maura Poli; Magdalena Gryzik; Lena Lifshitz; Esther G. Meyron-Holtz; Israel Vlodavsky; Paolo Arosio

doi:10.1371/journal.pone.0164183

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Peer-reviewed

Research Article

Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation

Michela Asperti,

Affiliation Molecular Biology laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123, Brescia, Italy
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Tanja Stuemler,

Affiliation Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, 32000, Haifa, Israel
⨯
Maura Poli,

Affiliation Molecular Biology laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123, Brescia, Italy
⨯
Magdalena Gryzik,

Affiliation Molecular Biology laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123, Brescia, Italy
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Lena Lifshitz,

Affiliation Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, 32000, Haifa, Israel
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Esther G. Meyron-Holtz,

Affiliation Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, 32000, Haifa, Israel
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Israel Vlodavsky,

Affiliation Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, 31096, Israel
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Paolo Arosio

* E-mail: paolo.arosio@unibs.it

Affiliation Molecular Biology laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123, Brescia, Italy

http://orcid.org/0000-0002-5343-8992

⨯

Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation

Michela Asperti,
Tanja Stuemler,
Maura Poli,
Magdalena Gryzik,
Lena Lifshitz,
Esther G. Meyron-Holtz,
Israel Vlodavsky,
Paolo Arosio

Published: October 6, 2016
https://doi.org/10.1371/journal.pone.0164183

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