Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis

Liza J. Burton; Mariela Rivera; Ohuod Hawsawi; Jin Zou; Tamaro Hudson; Guangdi Wang; Qiang Zhang; Luis Cubano; Nawal Boukli; Valerie Odero-Marah

doi:10.1371/journal.pone.0164115

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Peer-reviewed

Research Article

Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis

Liza J. Burton,

Affiliation Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, 30314, United States of America
⨯
Mariela Rivera,

Affiliation Department of Microbiology and Immunology, School of Medicine, Universidad Central del Caribe, Bayamon, PR, 00956, United States of America
⨯
Ohuod Hawsawi,

Affiliation Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, 30314, United States of America
⨯
Jin Zou,

Affiliation Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, 30314, United States of America
⨯
Tamaro Hudson,

Affiliation Department of Medicine, Howard University, Washington, DC, 20060, United States of America
⨯
Guangdi Wang,

Affiliation Department of Chemistry, Xavier University, New Orleans, LA, 70125, United States of America
⨯
Qiang Zhang,

Affiliation Department of Chemistry, Xavier University, New Orleans, LA, 70125, United States of America
⨯
Luis Cubano,

Affiliation Department of Microbiology and Immunology, School of Medicine, Universidad Central del Caribe, Bayamon, PR, 00956, United States of America
⨯
Nawal Boukli ,

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Microbiology and Immunology, School of Medicine, Universidad Central del Caribe, Bayamon, PR, 00956, United States of America
⨯
Valerie Odero-Marah

* E-mail: vodero_marah@cau.edu

¶‡ These authors are joint senior authors on this work.

Affiliation Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, 30314, United States of America
⨯

Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis

Liza J. Burton,
Mariela Rivera,
Ohuod Hawsawi,
Jin Zou,
Tamaro Hudson,
Guangdi Wang,
Qiang Zhang,
Luis Cubano,
Nawal Boukli,
Valerie Odero-Marah

Published: October 18, 2016
https://doi.org/10.1371/journal.pone.0164115

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Cytoskeletal proteins
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DNA-binding proteins
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Prostate cancer
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