MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Kelly E. Glajch; Laura Ferraiuolo; Kaly A. Mueller; Matthew J. Stopford; Varsha Prabhkar; Achille Gravanis; Pamela J. Shaw; Ghazaleh Sadri-Vakili

doi:10.1371/journal.pone.0164103

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Peer-reviewed

Research Article

MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Kelly E. Glajch,

Affiliation NeuroEpigenetics Laboratory, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Boston, MA, 02129–4404, United States of America
⨯
Laura Ferraiuolo,

Affiliation Sheffield Institute of Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, United Kingdom
⨯
Kaly A. Mueller,

Affiliation NeuroEpigenetics Laboratory, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Boston, MA, 02129–4404, United States of America
⨯
Matthew J. Stopford,

Affiliation Sheffield Institute of Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, United Kingdom
⨯
Varsha Prabhkar,

Affiliation NeuroEpigenetics Laboratory, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Boston, MA, 02129–4404, United States of America
⨯
Achille Gravanis,

Affiliation Department of Pharmacology, School of Medicine, University of Crete, Institute of Molecular Biology & Biotechnology-FORTH, Heraklion 71003, Greece
⨯
Pamela J. Shaw,

Affiliation Sheffield Institute of Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, United Kingdom
⨯
Ghazaleh Sadri-Vakili

* E-mail: gsadrivakili@mgh.harvard.edu

Affiliation NeuroEpigenetics Laboratory, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Boston, MA, 02129–4404, United States of America

http://orcid.org/0000-0003-3435-3544

⨯

MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Kelly E. Glajch,
Laura Ferraiuolo,
Kaly A. Mueller,
Matthew J. Stopford,
Varsha Prabhkar,
Achille Gravanis,
Pamela J. Shaw,
Ghazaleh Sadri-Vakili

Published: October 7, 2016
https://doi.org/10.1371/journal.pone.0164103

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