Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study

Rajeev K. Mehlotra; Noemi B. Hall; Barne Willie; Catherine M. Stein; Aaron Weinberg; Peter A. Zimmerman; Lance T. Vernon

doi:10.1371/journal.pone.0164075

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Research Article

Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study

Rajeev K. Mehlotra ,

Contributed equally to this work with: Rajeev K. Mehlotra, Noemi B. Hall, Barne Willie

* E-mail: rkm@case.edu (RKM); ltv1@case.edu (LTV)

Affiliation Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Noemi B. Hall ,

Contributed equally to this work with: Rajeev K. Mehlotra, Noemi B. Hall, Barne Willie

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Barne Willie ,

Contributed equally to this work with: Rajeev K. Mehlotra, Noemi B. Hall, Barne Willie

Current address: Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea

Affiliation Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Catherine M. Stein,

Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Aaron Weinberg,

Affiliation Department of Biological Sciences, Case Western Reserve University School of Dental Medicine, Cleveland, Ohio, United States of America
⨯
Peter A. Zimmerman,

Affiliation Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Lance T. Vernon

* E-mail: rkm@case.edu (RKM); ltv1@case.edu (LTV)

Affiliation Department of Pediatric and Community Dentistry, Case Western Reserve University School of Dental Medicine, Cleveland, Ohio, United States of America
⨯

Associations of Toll-Like Receptor and β-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study

Rajeev K. Mehlotra,
Noemi B. Hall,
Barne Willie,
Catherine M. Stein,
Aaron Weinberg,
Peter A. Zimmerman,
Lance T. Vernon

Published: October 11, 2016
https://doi.org/10.1371/journal.pone.0164075

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Toll-like receptors
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African American people
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Single nucleotide polymorphisms
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HIV
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Instrumental variable analysis
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Genetic polymorphism
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Highly-active antiretroviral therapy
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Linear regression analysis
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