Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression

• Yasuharu Shinoda ,

  Contributed equally to this work with: Yasuharu Shinoda, Hideaki Tagashira

  Affiliation Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, Japan

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• Hideaki Tagashira ,

  Contributed equally to this work with: Yasuharu Shinoda, Hideaki Tagashira

  Affiliation Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, Japan

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• Md. Shenuarin Bhuiyan,

  Affiliation Division of Molecular Cardiovascular Biology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, United States of America

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• Hideyuki Hasegawa,

  Affiliation Department of Electrical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6 Aramaki-Aoba, Aoba-ku, Sendai, Japan

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• Hiroshi Kanai,

  Affiliation Department of Electrical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6 Aramaki-Aoba, Aoba-ku, Sendai, Japan

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• Chen Zhang,

  Affiliation Department of Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 31005, P. R. China

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• Feng Han,

  Affiliation Department of Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 31005, P. R. China

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• Kohji Fukunaga

  * E-mail: kfukunaga@m.tohoku.ac.jp

  Affiliation Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, Japan

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