Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation

Yu Wang; Hua Guan; Da-Fei Xie; Yi Xie; Xiao-Dan Liu; Qi Wang; Li Sui; Man Song; Hong Zhang; Jianhua Zhou; Ping-Kun Zhou

doi:10.1371/journal.pone.0163896

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Open Access

Peer-reviewed

Research Article

Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation

Yu Wang ,

Contributed equally to this work with: Yu Wang, Hua Guan

Affiliation Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Hua Guan ,

Contributed equally to this work with: Yu Wang, Hua Guan

Affiliation Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Da-Fei Xie,

Affiliation Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Yi Xie,

Affiliation Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
⨯
Xiao-Dan Liu,

Affiliation Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Qi Wang,

Affiliation Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China
⨯
Li Sui,

Affiliation China Institute of Atomic Energy, Beijing 102413, China
⨯
Man Song,

Affiliations Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou, China
⨯
Hong Zhang,

Affiliation Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
⨯
Jianhua Zhou ,

* E-mail: zhoupk@bmi.ac.cn (PKZ); jianhua55@msn.com (JZ)

Affiliations iBioinfo Groups, Lexington, Massachusetts 02421, United States of America, Department of Neuroregeneration, Nantong University, Nantong, China
⨯
Ping-Kun Zhou

* E-mail: zhoupk@bmi.ac.cn (PKZ); jianhua55@msn.com (JZ)

Affiliations Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiation Biology, Beijing Institute of Radiation Medicine, Beijing, China, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou, China
⨯

Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation

Yu Wang,
Hua Guan,
Da-Fei Xie,
Yi Xie,
Xiao-Dan Liu,
Qi Wang,
Li Sui,
Man Song,
Hong Zhang,
Jianhua Zhou

Published: October 6, 2016
https://doi.org/10.1371/journal.pone.0163896

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Protein expression
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Proteomics
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Radiation therapy
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Protein metabolism
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