The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro

• Valery Golderman,

  Affiliation Laboratory for Neurological Research, Sheba Medical Center, Tel HaShomer, Israel

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• Efrat Shavit-Stein,

  Affiliation Department of Neurology, the Chaim Sheba Medical Center, Tel HaShomer, Israel

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• Ilia Tamarin,

  Affiliation Department of Hematology, Coagulation Laboratory, Sheba Medical Center, Tel HaShomer, Israel

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• Yossi Rosman,

  Affiliations Surgeon General Headquarters, Israel Defense Force Medical Corps, Tel Hashomer, Ramat Gan, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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• Shai Shrot,

  Affiliations Surgeon General Headquarters, Israel Defense Force Medical Corps, Tel Hashomer, Ramat Gan, Israel, Department of radiology, MedStar Georgetown University Hospital, Washington DC, United States of America

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• Nurit Rosenberg,

  Affiliation Department of Hematology, Coagulation Laboratory, Sheba Medical Center, Tel HaShomer, Israel

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• Nicola Maggio ,

  Contributed equally to this work with: Nicola Maggio, Joab Chapman, Arik Eisenkraft

  ¶‡ These authors are last authors on this work.

  Affiliations Department of Neurology, the Chaim Sheba Medical Center, Tel HaShomer, Israel, Department of Neurology, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

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• Joab Chapman ,

  Contributed equally to this work with: Nicola Maggio, Joab Chapman, Arik Eisenkraft

  ¶‡ These authors are last authors on this work.

  Affiliations Department of Neurology, the Chaim Sheba Medical Center, Tel HaShomer, Israel, Department of Neurology, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, Robert and Martha Harden Chair in Mental and Neurological Diseases Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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• Arik Eisenkraft

  Contributed equally to this work with: Nicola Maggio, Joab Chapman, Arik Eisenkraft

  * E-mail: aizenkra@gmail.com

  ¶‡ These authors are last authors on this work.

  Affiliations Surgeon General Headquarters, Israel Defense Force Medical Corps, Tel Hashomer, Ramat Gan, Israel, NBC Protection Division, IMoD, Hakyria, Tel Aviv, Israel, Institute for Research in Military Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel

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