Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

• Agustina Errea ,

  Contributed equally to this work with: Agustina Errea, Delphine Cayet

  Affiliation Instituto de Estudios Inmunológicos y Fisiopatológicos–CONICET- Nacional Universtity of La Plata, 1900, La Plata, Argentina

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• Delphine Cayet ,

  Contributed equally to this work with: Agustina Errea, Delphine Cayet

  Affiliation Institut Pasteur de Lille, Inserm, CNRS, Univ. Lille, CHU Lille, U1019—UMR8204—CIIL—Center for Infection and Immunity of Lille, F-59000, Lille, France

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• Philippe Marchetti,

  Affiliation Univ. Lille, Inserm, CHU Lille, UMR-S 1172—JPArc—Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France

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• Cong Tang,

  Affiliation Department of Pharmacology, Max Planck Institute for Heart and Lung Research, D-61231, Bad Nauheim, Germany

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• Jerome Kluza,

  Affiliation Univ. Lille, Inserm, CHU Lille, UMR-S 1172—JPArc—Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France

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• Stefan Offermanns,

  Affiliations Department of Pharmacology, Max Planck Institute for Heart and Lung Research, D-61231, Bad Nauheim, Germany, Medical Faculty, J.W. Goethe University, D-60590, Frankfurt, Germany

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• Jean-Claude Sirard,

  Affiliation Institut Pasteur de Lille, Inserm, CNRS, Univ. Lille, CHU Lille, U1019—UMR8204—CIIL—Center for Infection and Immunity of Lille, F-59000, Lille, France

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• Martin Rumbo

  * E-mail: martinr@biol.unlp.edu.ar

  Affiliation Instituto de Estudios Inmunológicos y Fisiopatológicos–CONICET- Nacional Universtity of La Plata, 1900, La Plata, Argentina

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