Potency Biomarker Signature Genes from Multiparametric Osteogenesis Assays: Will cGMP Human Bone Marrow Mesenchymal Stromal Cells Make Bone?

Alba Murgia; Elena Veronesi; Olivia Candini; Anna Caselli; Naomi D’souza; Valeria Rasini; Andrea Giorgini; Fabio Catani; Lorenzo Iughetti; Massimo Dominici; Jorge S. Burns

doi:10.1371/journal.pone.0163629

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Open Access

Peer-reviewed

Research Article

Potency Biomarker Signature Genes from Multiparametric Osteogenesis Assays: Will cGMP Human Bone Marrow Mesenchymal Stromal Cells Make Bone?

Alba Murgia,

Affiliation Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia
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Elena Veronesi,

Affiliations Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia, TPM, Science & Technology Park for Medicine, Mirandola, Modena, Italia
⨯
Olivia Candini,

Affiliation Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia
⨯
Anna Caselli,

Affiliation CVBF - Consorzio per le Valutazioni Biologiche e Farmacologiche, Ospedale Pediatrico Giovanni XXIII, Bari, Italia
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Naomi D’souza,

Affiliation Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia
⨯
Valeria Rasini,

Affiliation Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia
⨯
Andrea Giorgini,

Affiliation Department of Orthopedic Surgery, University Hospital of Modena and Reggio Emilia, Modena, Italia
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Fabio Catani,

Affiliation Department of Orthopedic Surgery, University Hospital of Modena and Reggio Emilia, Modena, Italia
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Lorenzo Iughetti,

Affiliation Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia
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Massimo Dominici ,

Contributed equally to this work with: Massimo Dominici, Jorge S. Burns

* E-mail: massimo.dominici@unimore.it (MD); jorge.burns@unimore.it (JSB)

Affiliations Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia, TPM, Science & Technology Park for Medicine, Mirandola, Modena, Italia
⨯
Jorge S. Burns

Contributed equally to this work with: Massimo Dominici, Jorge S. Burns

* E-mail: massimo.dominici@unimore.it (MD); jorge.burns@unimore.it (JSB)

Affiliations Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Modena, Italia, TPM, Science & Technology Park for Medicine, Mirandola, Modena, Italia

http://orcid.org/0000-0002-8602-1536

⨯

Potency Biomarker Signature Genes from Multiparametric Osteogenesis Assays: Will cGMP Human Bone Marrow Mesenchymal Stromal Cells Make Bone?

Alba Murgia,
Elena Veronesi,
Olivia Candini,
Anna Caselli,
Naomi D’souza,
Valeria Rasini,
Andrea Giorgini,
Fabio Catani,
Lorenzo Iughetti,
Massimo Dominici

Published: October 6, 2016
https://doi.org/10.1371/journal.pone.0163629

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Biomarkers
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Gene expression
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Bone development
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Alizarin staining
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Cell differentiation
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