Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E2 Synthase 1 and Ser127 Is Not

Joan Raouf; Nazmi Rafique; Michael Christopher Goodman; Helena Idborg; Filip Bergqvist; Richard N. Armstrong; Per-Johan Jakobsson; Ralf Morgenstern; Linda Spahiu

doi:10.1371/journal.pone.0163600

Loading metrics

Open Access

Peer-reviewed

Research Article

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E₂ Synthase 1 and Ser127 Is Not

Joan Raouf,

Affiliations Unit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, SE-171 76, Stockholm, Sweden, Unit of Rheumatology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden

http://orcid.org/0000-0001-6808-7024

⨯
Nazmi Rafique,

Affiliation Institute of Environmental Medicine, Division of Biochemical Toxicology, Karolinska Institutet, Stockholm, Sweden
⨯
Michael Christopher Goodman,

Affiliation Department of Chemistry, Vanderbilt University School of Medicine, Nashville, United States of America
⨯
Helena Idborg,

Affiliations Unit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, SE-171 76, Stockholm, Sweden, Unit of Rheumatology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden
⨯
Filip Bergqvist,

Affiliations Unit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, SE-171 76, Stockholm, Sweden, Unit of Rheumatology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden
⨯
Richard N. Armstrong †,

† Deceased.

Affiliation Department of Chemistry, Vanderbilt University School of Medicine, Nashville, United States of America
⨯
Per-Johan Jakobsson,

Affiliations Unit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, SE-171 76, Stockholm, Sweden, Unit of Rheumatology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden
⨯
Ralf Morgenstern ,

Contributed equally to this work with: Ralf Morgenstern, Linda Spahiu

* E-mail: linda.spahiu@ki.se (LS); ralf.morgenstern@ki.se (RM)

Affiliation Institute of Environmental Medicine, Division of Biochemical Toxicology, Karolinska Institutet, Stockholm, Sweden
⨯
Linda Spahiu

Contributed equally to this work with: Ralf Morgenstern, Linda Spahiu

* E-mail: linda.spahiu@ki.se (LS); ralf.morgenstern@ki.se (RM)

Affiliation Institute of Environmental Medicine, Division of Biochemical Toxicology, Karolinska Institutet, Stockholm, Sweden
⨯

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E₂ Synthase 1 and Ser127 Is Not

Joan Raouf,
Nazmi Rafique,
Michael Christopher Goodman,
Helena Idborg,
Filip Bergqvist,
Richard N. Armstrong,
Per-Johan Jakobsson,
Ralf Morgenstern,
Linda Spahiu

Published: September 29, 2016
https://doi.org/10.1371/journal.pone.0163600

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Protons
Is the Subject Area "Protons" applicable to this article?

Thanks for your feedback.
Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Enzyme purification
Is the Subject Area "Enzyme purification" applicable to this article?

Thanks for your feedback.
Prostaglandin
Is the Subject Area "Prostaglandin" applicable to this article?

Thanks for your feedback.
Glutathione
Is the Subject Area "Glutathione" applicable to this article?

Thanks for your feedback.
Glycerol
Is the Subject Area "Glycerol" applicable to this article?

Thanks for your feedback.
Liquid chromatography-mass spectrometry
Is the Subject Area "Liquid chromatography-mass spectrometry" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.