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Open Access

Peer-reviewed

Research Article

NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice

Madhavi Puchalapalli,

Current address: Department of Pathology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

Affiliation Department of Pathology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Xianke Zeng,

Affiliation Department of Pathology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Liang Mu,

Affiliation Department of Pathology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Aubree Anderson,

Affiliation Department of Pathology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Laura Hix Glickman,

Current address: Aduro Biotech, Inc. Berkeley, California, United States of America

Affiliation Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Ming Zhang,

Affiliation Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Megan R. Sayyad,

Affiliation Department of Pathology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
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Sierra Mosticone Wangensteen,

Affiliation Department of Pathology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
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Charles V. Clevenger,

Current address: Department of Pathology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

Affiliation Department of Pathology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
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Jennifer E. Koblinski

* E-mail: jennifer.koblinski@vcuhealth.org

Current address: Department of Pathology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

Affiliation Department of Pathology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Institute, Northwestern University, Chicago, Illinois, United States of America
⨯

NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice

Madhavi Puchalapalli,
Xianke Zeng,
Liang Mu,
Aubree Anderson,
Laura Hix Glickman,
Ming Zhang,
Megan R. Sayyad,
Sierra Mosticone Wangensteen,
Charles V. Clevenger,
Jennifer E. Koblinski

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Published: September 23, 2016
https://doi.org/10.1371/journal.pone.0163521

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Breast cancer
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Brain metastasis
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Genetically modified animals
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Mouse models
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Lung and intrathoracic tumors
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Metastasis
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Lymph nodes
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Spinal metastasis
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