Identification of Genome-Wide Mutations in Ciprofloxacin-Resistant F. tularensis LVS Using Whole Genome Tiling Arrays and Next Generation Sequencing

Crystal J. Jaing; Kevin S. McLoughlin; James B. Thissen; Adam Zemla; Shea N. Gardner; Lisa M. Vergez; Feliza Bourguet; Shalini Mabery; Viacheslav Y. Fofanov; Heather Koshinsky; Paul J. Jackson

doi:10.1371/journal.pone.0163458

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Open Access

Peer-reviewed

Research Article

Identification of Genome-Wide Mutations in Ciprofloxacin-Resistant F. tularensis LVS Using Whole Genome Tiling Arrays and Next Generation Sequencing

Crystal J. Jaing ,

* E-mail: jaing2@llnl.gov

Affiliation Physical Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Kevin S. McLoughlin,

Affiliation Computations Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
James B. Thissen,

Affiliation Physical Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Adam Zemla,

Affiliation Computations Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Shea N. Gardner †,

† Deceased.

Affiliation Computations Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Lisa M. Vergez,

Affiliation Physical Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Feliza Bourguet,

Affiliation Physical Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Shalini Mabery,

Affiliation Physical Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯
Viacheslav Y. Fofanov,

Current address: Northern Arizona State University, Flagstaff, AZ, 86011, United States of America

Affiliation Eureka Genomics, Hercules, CA, 94547, United States of America
⨯
Heather Koshinsky,

Current address: Affymetrix, Santa Clara, CA, 95051, United States of America

Affiliation Eureka Genomics, Hercules, CA, 94547, United States of America
⨯
Paul J. Jackson

Affiliation Physical Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, United States of America
⨯

Identification of Genome-Wide Mutations in Ciprofloxacin-Resistant F. tularensis LVS Using Whole Genome Tiling Arrays and Next Generation Sequencing

Crystal J. Jaing,
Kevin S. McLoughlin,
James B. Thissen,
Adam Zemla,
Shea N. Gardner,
Lisa M. Vergez,
Feliza Bourguet,
Shalini Mabery,
Viacheslav Y. Fofanov,
Heather Koshinsky

Published: September 26, 2016
https://doi.org/10.1371/journal.pone.0163458

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Francisella tularensis
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Single nucleotide polymorphisms
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