Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes

Wakako Murakami; Shigeki Kobayashi; Takehisa Susa; Takuma Nanno; Hironori Ishiguchi; Takeki Myoren; Shigehiko Nishimura; Takayoshi Kato; Akihiro Hino; Tetsuro Oda; Shinichi Okuda; Takeshi Yamamoto; Masafumi Yano

doi:10.1371/journal.pone.0163250

Loading metrics

Open Access

Peer-reviewed

Research Article

Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca²⁺ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes

Wakako Murakami ,

Contributed equally to this work with: Wakako Murakami, Shigeki Kobayashi

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Shigeki Kobayashi ,

Contributed equally to this work with: Wakako Murakami, Shigeki Kobayashi

* E-mail: skoba@yamaguchi-u.ac.jp

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Takehisa Susa,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Takuma Nanno,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Hironori Ishiguchi,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Takeki Myoren,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Shigehiko Nishimura,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Takayoshi Kato,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Akihiro Hino,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Tetsuro Oda,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Shinichi Okuda,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Takeshi Yamamoto,

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯
Masafumi Yano

Affiliation Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755–8505, Japan
⨯

Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca²⁺ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes

Wakako Murakami,
Shigeki Kobayashi,
Takehisa Susa,
Takuma Nanno,
Hironori Ishiguchi,
Takeki Myoren,
Shigehiko Nishimura,
Takayoshi Kato,
Akihiro Hino,
Tetsuro Oda

Published: September 22, 2016
https://doi.org/10.1371/journal.pone.0163250

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cardiomyocytes
Is the Subject Area "Cardiomyocytes" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Atrial natriuretic peptide
Is the Subject Area "Atrial natriuretic peptide" applicable to this article?

Thanks for your feedback.
Heart failure
Is the Subject Area "Heart failure" applicable to this article?

Thanks for your feedback.
Dogs
Is the Subject Area "Dogs" applicable to this article?

Thanks for your feedback.
Immunohistochemistry techniques
Is the Subject Area "Immunohistochemistry techniques" applicable to this article?

Thanks for your feedback.
Reactive oxygen species
Is the Subject Area "Reactive oxygen species" applicable to this article?

Thanks for your feedback.
Mitochondrial DNA
Is the Subject Area "Mitochondrial DNA" applicable to this article?

Thanks for your feedback.