Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity

Vishal R. Mali; Guodong Pan; Mandar Deshpande; Rajarajan A. Thandavarayan; Jiang Xu; Xiao-Ping Yang; Suresh S. Palaniyandi

doi:10.1371/journal.pone.0163158

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Peer-reviewed

Research Article

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity

Vishal R. Mali ,

Contributed equally to this work with: Vishal R. Mali, Guodong Pan

Affiliation Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, United States of America
⨯
Guodong Pan ,

Contributed equally to this work with: Vishal R. Mali, Guodong Pan

Affiliation Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, United States of America
⨯
Mandar Deshpande,

Affiliation Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, United States of America
⨯
Rajarajan A. Thandavarayan,

Affiliation Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX, United States of America
⨯
Jiang Xu,

Affiliation Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, United States of America
⨯
Xiao-Ping Yang,

Affiliation Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, United States of America
⨯
Suresh S. Palaniyandi

* E-mail: spalani2@hfhs.org

Affiliations Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, United States of America, Department of Physiology, Wayne State University, Detroit, MI, United States of America
⨯

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity

Vishal R. Mali,
Guodong Pan,
Mandar Deshpande,
Rajarajan A. Thandavarayan,
Jiang Xu,
Xiao-Ping Yang,
Suresh S. Palaniyandi

Published: October 13, 2016
https://doi.org/10.1371/journal.pone.0163158

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