Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

Han-Kyu Lee; Clara Velazquez Sanchez; Mei Chen; Peter J. Morin; John M. Wells; Eugene B. Hanlon; Weiming Xia

doi:10.1371/journal.pone.0163072

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Peer-reviewed

Research Article

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

Han-Kyu Lee,

Affiliations Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America, Department of Neurology, Rhode Island Hospital and Brown University Warren Alpert Medical School, Providence, RI, United States of America
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Clara Velazquez Sanchez,

Affiliations Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States of America
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Mei Chen,

Affiliations Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America
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Peter J. Morin,

Affiliation Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America
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John M. Wells,

Affiliation Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America
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Eugene B. Hanlon,

Affiliations Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America, Medical Research & Development Service, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America
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Weiming Xia

* E-mail: weiming.xia@va.gov

Affiliations Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, United States of America, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States of America

http://orcid.org/0000-0002-7463-3295

⨯

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

Han-Kyu Lee,
Clara Velazquez Sanchez,
Mei Chen,
Peter J. Morin,
John M. Wells,
Eugene B. Hanlon,
Weiming Xia

Published: September 29, 2016
https://doi.org/10.1371/journal.pone.0163072

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Alzheimer's disease
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