Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues

Gregory Lacraz; Volatiana Rakotoarivelo; Sebastien M. Labbé; Mathieu Vernier; Christophe Noll; Marian Mayhue; Jana Stankova; Adel Schwertani; Guillaume Grenier; André Carpentier; Denis Richard; Gerardo Ferbeyre; Julie Fradette; Marek Rola-Pleszczynski; Alfredo Menendez; Marie-France Langlois; Subburaj Ilangumaran; Sheela Ramanathan

doi:10.1371/journal.pone.0162995

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Open Access

Peer-reviewed

Research Article

Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues

Gregory Lacraz,

Current address: Hubrecht Institute, University Medical Center, Utrecht, The Netherlands

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Volatiana Rakotoarivelo,

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Sebastien M. Labbé,

Affiliation Institut Universitaire de Cardiologie et de Pneumologie, Québec City, Québec, Canada
⨯
Mathieu Vernier,

Affiliation Department of Biochemistry, University of Montréal, Montreal, Québec, Canada
⨯
Christophe Noll,

Affiliation Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Marian Mayhue,

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Jana Stankova,

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Adel Schwertani,

Affiliation Department of Cardiology, McGill University, Montreal, Québec, Canada
⨯
Guillaume Grenier,

Affiliation Department of Surgery, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
André Carpentier,

Affiliation Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Denis Richard,

Affiliation Institut Universitaire de Cardiologie et de Pneumologie, Québec City, Québec, Canada
⨯
Gerardo Ferbeyre,

Affiliation Department of Biochemistry, University of Montréal, Montreal, Québec, Canada
⨯
Julie Fradette,

Affiliation Department of Surgery, Laval University, CRCHU de Québec-Université Laval, Québec, Canada
⨯
Marek Rola-Pleszczynski,

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Alfredo Menendez,

Affiliation Department of Microbiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Marie-France Langlois,

Affiliation Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
Subburaj Ilangumaran,

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
⨯
[ ... ],
Sheela Ramanathan

* E-mail: Sheela.Ramanathan@Usherbrooke.ca

Affiliation Division of Immunology, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, CRCHUS, Sherbrooke, Québec, Canada
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Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues

Gregory Lacraz,
Volatiana Rakotoarivelo,
Sebastien M. Labbé,
Mathieu Vernier,
Christophe Noll,
Marian Mayhue,
Jana Stankova,
Adel Schwertani,
Guillaume Grenier,
André Carpentier

Published: September 29, 2016
https://doi.org/10.1371/journal.pone.0162995

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Adipocytes
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Inflammation
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Brown adipose tissue
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Obesity
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Adipocyte differentiation
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Thermogenesis
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Lipids
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Adipose tissue
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