Dental Calculus Stimulates Interleukin-1β Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes

• Jorge Luis Montenegro Raudales,

  Affiliation Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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• Atsutoshi Yoshimura ,

  * E-mail: ayoshi@nagasaki-u.ac.jp

  Affiliation Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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• Ziauddin SM,

  Affiliation Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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• Takashi Kaneko,

  Affiliation Center for Oral Diseases, Fukuoka Dental College, Fukuoka, Japan

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• Yukio Ozaki,

  Affiliation Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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• Takashi Ukai,

  Affiliation Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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• Toshihiro Miyazaki,

  Affiliation Department of Cell Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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• Eicke Latz,

  Affiliations University Hospital, University of Bonn, Bonn, Germany, Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, German Center for Neurodegenerative Diseases, Bonn, Germany, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway

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• Yoshitaka Hara

  Affiliation Department of Periodontology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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