Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells

• Yong-Chao Ma ,

  Contributed equally to this work with: Yong-Chao Ma, Zhi-Xin Wang, Shao-Ju Jin

  Affiliations Clinical Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China, The First Affiliated Hospital of Luohe Medical College, Luohe, Henan, P.R. China, Tumor Occurrence and Prevention Research Innovation team of Luohe, Luohe, Henan, P.R. China

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• Zhi-Xin Wang ,

  Contributed equally to this work with: Yong-Chao Ma, Zhi-Xin Wang, Shao-Ju Jin

  Affiliation Basic Medical Institute of ZhengZhou University, ZhengZhou, Henan, P.R. China

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• Shao-Ju Jin ,

  Contributed equally to this work with: Yong-Chao Ma, Zhi-Xin Wang, Shao-Ju Jin

  Affiliation Institute of pharmacology of Luohe Medical College, Luohe, Henan, P.R. China

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• Yan-Xin Zhang,

  Affiliation Basic Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China

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• Guo-Qiang Hu,

  Affiliation Institute of Chemistry and Biology of Henan University, Kaifeng, Henan, P.R. China

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• Dong-Tao Cui,

  Affiliation Clinical Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China

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• Jiang-Shuan Wang,

  Affiliation Basic Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China

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• Min Wang,

  Affiliation Clinical Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China

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• Fu-Qing Wang ,

  * E-mail: 13839527381@163.com (ZJZ); lhyzxswyh@163.com (FQW)

  Affiliation Basic Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China

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• Zhi-Jun Zhao

  * E-mail: 13839527381@163.com (ZJZ); lhyzxswyh@163.com (FQW)

  Affiliation Clinical Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China

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