High-Grade Salivary-Gland Involvement, Assessed by Histology or Ultrasonography, Is Associated with a Poor Response to a Single Rituximab Course in Primary Sjögren’s Syndrome: Data from the TEARS Randomized Trial

Divi Cornec; Sandrine Jousse-Joulin; Sebastian Costa; Thierry Marhadour; Pascale Marcorelles; Jean-Marie Berthelot; Eric Hachulla; Pierre-Yves Hatron; Vincent Goeb; Olivier Vittecoq; Emmanuel Nowak; Jacques-Olivier Pers; Valérie Devauchelle-Pensec; Alain Saraux

doi:10.1371/journal.pone.0162787

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Research Article

High-Grade Salivary-Gland Involvement, Assessed by Histology or Ultrasonography, Is Associated with a Poor Response to a Single Rituximab Course in Primary Sjögren’s Syndrome: Data from the TEARS Randomized Trial

Divi Cornec,

Affiliations Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, Boulevard Tanguy Prigent, 29609 Brest, France, EA2216, INSERM ESPRI, ERI29, Laboratoire d’Immunothérapies et Pathologies lymphocytaires B, Université de Brest, and Labex "IGO", Brest, France
⨯
Sandrine Jousse-Joulin,

Affiliations Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, Boulevard Tanguy Prigent, 29609 Brest, France, EA2216, INSERM ESPRI, ERI29, Laboratoire d’Immunothérapies et Pathologies lymphocytaires B, Université de Brest, and Labex "IGO", Brest, France
⨯
Sebastian Costa,

Affiliation Laboratoire d’Anatomie Pathologique et Cytologie, Hôpital Morvan, CHRU Brest, Avenue Foch, 29609 Brest, France
⨯
Thierry Marhadour,

Affiliation Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, Boulevard Tanguy Prigent, 29609 Brest, France
⨯
Pascale Marcorelles,

Affiliation Laboratoire d’Anatomie Pathologique et Cytologie, Hôpital Morvan, CHRU Brest, Avenue Foch, 29609 Brest, France
⨯
Jean-Marie Berthelot,

Affiliation Service de Rhumatologie, Hôtel-Dieu, CHU Nantes, 44093 Nantes Cedex 01, France
⨯
Eric Hachulla,

Affiliation Service de Médecine Interne, Claude Huriez Hospital, Université Lille Nord-de-France, 59037 Lille Cedex, France
⨯
Pierre-Yves Hatron,

Affiliation Service de Médecine Interne, Claude Huriez Hospital, Université Lille Nord-de-France, 59037 Lille Cedex, France
⨯
Vincent Goeb,

Affiliation Service de Rhumatologie, CHRU de Rouen, 76230 Bois-Guillaume, France
⨯
Olivier Vittecoq,

Affiliation Service de Rhumatologie, CHRU de Rouen, 76230 Bois-Guillaume, France
⨯
Emmanuel Nowak,

Affiliation INSERM CIC 0502, CHU Brest, Brest, France
⨯
Jacques-Olivier Pers,

Affiliation EA2216, INSERM ESPRI, ERI29, Laboratoire d’Immunothérapies et Pathologies lymphocytaires B, Université de Brest, and Labex "IGO", Brest, France
⨯
Valérie Devauchelle-Pensec,

Affiliations Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, Boulevard Tanguy Prigent, 29609 Brest, France, EA2216, INSERM ESPRI, ERI29, Laboratoire d’Immunothérapies et Pathologies lymphocytaires B, Université de Brest, and Labex "IGO", Brest, France
⨯
Alain Saraux

* E-mail: alain.saraux@chu-brest.fr

Affiliations Service de Rhumatologie, Hôpital de la Cavale Blanche, CHRU Brest, Boulevard Tanguy Prigent, 29609 Brest, France, EA2216, INSERM ESPRI, ERI29, Laboratoire d’Immunothérapies et Pathologies lymphocytaires B, Université de Brest, and Labex "IGO", Brest, France
⨯

High-Grade Salivary-Gland Involvement, Assessed by Histology or Ultrasonography, Is Associated with a Poor Response to a Single Rituximab Course in Primary Sjögren’s Syndrome: Data from the TEARS Randomized Trial

Divi Cornec,
Sandrine Jousse-Joulin,
Sebastian Costa,
Thierry Marhadour,
Pascale Marcorelles,
Jean-Marie Berthelot,
Eric Hachulla,
Pierre-Yves Hatron,
Vincent Goeb,
Olivier Vittecoq

Published: September 23, 2016
https://doi.org/10.1371/journal.pone.0162787

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