Transcriptomic Analysis of Persistent Infection with Foot-and-Mouth Disease Virus in Cattle Suggests Impairment of Apoptosis and Cell-Mediated Immunity in the Nasopharynx

Michael Eschbaumer; Carolina Stenfeldt; George R. Smoliga; Juan M. Pacheco; Luis L. Rodriguez; Robert W. Li; James Zhu; Jonathan Arzt

doi:10.1371/journal.pone.0162750

Loading metrics

Open Access

Peer-reviewed

Research Article

Transcriptomic Analysis of Persistent Infection with Foot-and-Mouth Disease Virus in Cattle Suggests Impairment of Apoptosis and Cell-Mediated Immunity in the Nasopharynx

Michael Eschbaumer,

Current address: Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany

Affiliations Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America, Oak Ridge Institute for Science and Education, PIADC Research Participation Program, Oak Ridge, TN, United States of America

http://orcid.org/0000-0002-1104-0695

⨯
Carolina Stenfeldt,

Affiliations Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America, Oak Ridge Institute for Science and Education, PIADC Research Participation Program, Oak Ridge, TN, United States of America
⨯
George R. Smoliga,

Affiliation Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America
⨯
Juan M. Pacheco,

Affiliation Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America
⨯
Luis L. Rodriguez,

Affiliation Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America
⨯
Robert W. Li,

Affiliation Animal Genomics and Improvement Laboratory (AGIL), USDA-ARS, Beltsville, MD, United States of America
⨯
James Zhu ,

* E-mail: james.zhu@ars.usda.gov (JZ); jonathan.arzt@ars.usda.gov (JA)

Affiliation Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America
⨯
Jonathan Arzt

* E-mail: james.zhu@ars.usda.gov (JZ); jonathan.arzt@ars.usda.gov (JA)

Affiliation Plum Island Animal Disease Center (PIADC), Foreign Animal Disease Research Unit (FADRU), United States Department of Agriculture (USDA)—Agricultural Research Service (ARS), Greenport, NY, United States of America
⨯

Transcriptomic Analysis of Persistent Infection with Foot-and-Mouth Disease Virus in Cattle Suggests Impairment of Apoptosis and Cell-Mediated Immunity in the Nasopharynx

Michael Eschbaumer,
Carolina Stenfeldt,
George R. Smoliga,
Juan M. Pacheco,
Luis L. Rodriguez,
Robert W. Li,
James Zhu,
Jonathan Arzt

Published: September 19, 2016
https://doi.org/10.1371/journal.pone.0162750

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Viral persistence and latency
Is the Subject Area "Viral persistence and latency" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
T cell receptors
Is the Subject Area "T cell receptors" applicable to this article?

Thanks for your feedback.
Foot and mouth disease
Is the Subject Area "Foot and mouth disease" applicable to this article?

Thanks for your feedback.