GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes

Kambis Sadeghi; Lukas Wisgrill; Isabelle Wessely; Susanne C. Diesner; Simone Schüller; Celia Dürr; Armando Heinle; Monika Sachet; Arnold Pollak; Elisabeth Förster-Waldl; Andreas Spittler

doi:10.1371/journal.pone.0162667

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Open Access

Peer-reviewed

Research Article

GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes

Kambis Sadeghi,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Lukas Wisgrill,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Isabelle Wessely,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Susanne C. Diesner,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Simone Schüller,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Celia Dürr,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Armando Heinle,

Affiliation Dept. of Surgery, Medical University of Vienna, Vienna, Austria
⨯
Monika Sachet,

Affiliation Dept. of Surgery, Medical University of Vienna, Vienna, Austria
⨯
Arnold Pollak,

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Elisabeth Förster-Waldl ,

* E-mail: elisabeth.foerster-waldl@meduniwien.ac.at

Affiliation Dept. of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Medical University of Vienna, Vienna, Austria
⨯
Andreas Spittler

Affiliation Core Facility Flow Cytometry, Medical University of Vienna, Vienna, Austria
⨯

GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes

Kambis Sadeghi,
Lukas Wisgrill,
Isabelle Wessely,
Susanne C. Diesner,
Simone Schüller,
Celia Dürr,
Armando Heinle,
Monika Sachet,
Arnold Pollak,
Elisabeth Förster-Waldl

Published: October 3, 2016
https://doi.org/10.1371/journal.pone.0162667

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Monocytes
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Toll-like receptors
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Cytokines
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Flow cytometry
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Transcription factors
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Immune receptor signaling
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Cell staining
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Transcriptional control
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