Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress

Scott M. Thompson; Matthew R. Callstrom; Danielle E. Jondal; Kim A. Butters; Bruce E. Knudsen; Jill L. Anderson; Karen R. Lien; Shari L. Sutor; Ju-Seog Lee; Snorri S. Thorgeirsson; Joseph P. Grande; Lewis R. Roberts; David A. Woodrum

doi:10.1371/journal.pone.0162634

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Peer-reviewed

Research Article

Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress

Scott M. Thompson ,

* E-mail: thompson.scott@mayo.edu (SMT); woodrum.david@mayo.edu (DAW)

Affiliation Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Matthew R. Callstrom,

Affiliation Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Danielle E. Jondal,

Affiliation Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Kim A. Butters,

Affiliation Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Bruce E. Knudsen,

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Jill L. Anderson,

Affiliation Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Karen R. Lien,

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Shari L. Sutor,

Affiliation Genomics Research Center, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Ju-Seog Lee,

Affiliation Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
⨯
Snorri S. Thorgeirsson,

Affiliation Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Joseph P. Grande,

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
Lewis R. Roberts,

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯
David A. Woodrum

* E-mail: thompson.scott@mayo.edu (SMT); woodrum.david@mayo.edu (DAW)

Affiliation Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America
⨯

Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress

Scott M. Thompson,
Matthew R. Callstrom,
Danielle E. Jondal,
Kim A. Butters,
Bruce E. Knudsen,
Jill L. Anderson,
Karen R. Lien,
Shari L. Sutor,
Ju-Seog Lee,
Snorri S. Thorgeirsson

Published: September 9, 2016
https://doi.org/10.1371/journal.pone.0162634

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Thermal stresses
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Cancers and neoplasms
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Hepatocellular carcinoma
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Stress signaling cascade
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Hyperthermia
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Hepatocytes
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Signal inhibition
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Gene expression
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