Lebetin 2, a Snake Venom-Derived Natriuretic Peptide, Attenuates Acute Myocardial Ischemic Injury through the Modulation of Mitochondrial Permeability Transition Pore at the Time of Reperfusion

Bochra Tourki; Philippe Matéo; Jessica Morand; Mohamed Elayeb; Diane Godin-Ribuot; Naziha Marrakchi; Elise Belaidi; Erij Messadi

doi:10.1371/journal.pone.0162632

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Research Article

Lebetin 2, a Snake Venom-Derived Natriuretic Peptide, Attenuates Acute Myocardial Ischemic Injury through the Modulation of Mitochondrial Permeability Transition Pore at the Time of Reperfusion

Bochra Tourki,

Affiliations Laboratoire des Venins et Biomolécules Thérapeutiques (LR11IPT08) et Plateforme de Physiologie et de Physiopathologie Cardiovasculaires (P2C), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia, Université Carthage Tunis, Bizerte, Tunisia
⨯
Philippe Matéo,

Affiliation Laboratoire de Signalisation et Physiopathologie Cardiovasculaire, UMR-S 1180, Faculté de Pharmacie, Université Paris Sud, Paris, France
⨯
Jessica Morand,

Affiliation Laboratoire d’Hypoxie et Physiopathologie Cardiaque, Inserm U1042, Faculté de Pharmacie, Université Grenoble Alpes, Grenoble, France
⨯
Mohamed Elayeb,

Affiliation Laboratoire des Venins et Biomolécules Thérapeutiques (LR11IPT08) et Plateforme de Physiologie et de Physiopathologie Cardiovasculaires (P2C), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia
⨯
Diane Godin-Ribuot,

Affiliation Laboratoire d’Hypoxie et Physiopathologie Cardiaque, Inserm U1042, Faculté de Pharmacie, Université Grenoble Alpes, Grenoble, France
⨯
Naziha Marrakchi,

Affiliation Laboratoire des Venins et Biomolécules Thérapeutiques (LR11IPT08) et Plateforme de Physiologie et de Physiopathologie Cardiovasculaires (P2C), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia
⨯
Elise Belaidi,

Affiliation Laboratoire d’Hypoxie et Physiopathologie Cardiaque, Inserm U1042, Faculté de Pharmacie, Université Grenoble Alpes, Grenoble, France
⨯
Erij Messadi

* E-mail: erij.messadi@pasteur.rns.tn

Affiliation Laboratoire des Venins et Biomolécules Thérapeutiques (LR11IPT08) et Plateforme de Physiologie et de Physiopathologie Cardiovasculaires (P2C), Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia
⨯

Lebetin 2, a Snake Venom-Derived Natriuretic Peptide, Attenuates Acute Myocardial Ischemic Injury through the Modulation of Mitochondrial Permeability Transition Pore at the Time of Reperfusion

Bochra Tourki,
Philippe Matéo,
Jessica Morand,
Mohamed Elayeb,
Diane Godin-Ribuot,
Naziha Marrakchi,
Elise Belaidi,
Erij Messadi

Published: September 12, 2016
https://doi.org/10.1371/journal.pone.0162632

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