Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice

Marjo M. P. C. Donners; Lili Bai; Suzanne P. M. Lutgens; Erwin Wijnands; Jason Johnson; Leon J. Schurgers; Cong-Lin Liu; Mat J. A. P. Daemen; Kitty B. J. M. Cleutjens; Guo-Ping Shi; Erik A. L. Biessen; Sylvia Heeneman

doi:10.1371/journal.pone.0162595

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Peer-reviewed

Research Article

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE^-/- Mice

Marjo M. P. C. Donners ,

Contributed equally to this work with: Marjo M. P. C. Donners, Lili Bai

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Lili Bai ,

Contributed equally to this work with: Marjo M. P. C. Donners, Lili Bai

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Suzanne P. M. Lutgens,

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
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Erwin Wijnands,

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
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Jason Johnson,

Affiliation Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Marlbrough Street, Bristol, BS2 8HW, United Kingdom
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Leon J. Schurgers,

Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
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Cong-Lin Liu,

Affiliation Cardiovascular Medicine, Brigham and Women's Hospital, NRB-742, 77 Avenue Louis Pasteur, Boston, Massachusetts, 02115, United States of America
⨯
Mat J. A. P. Daemen,

Affiliations Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands, Department of Pathology, Amsterdam Medical Center, Amsterdam, The Netherlands
⨯
Kitty B. J. M. Cleutjens,

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Guo-Ping Shi,

Affiliation Cardiovascular Medicine, Brigham and Women's Hospital, NRB-742, 77 Avenue Louis Pasteur, Boston, Massachusetts, 02115, United States of America
⨯
Erik A. L. Biessen,

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
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Sylvia Heeneman

* E-mail: S.heeneman@maastrichtuniversity.nl

Affiliation Experimental Vascular Pathology group, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE^-/- Mice

Marjo M. P. C. Donners,
Lili Bai,
Suzanne P. M. Lutgens,
Erwin Wijnands,
Jason Johnson,
Leon J. Schurgers,
Cong-Lin Liu,
Mat J. A. P. Daemen,
Kitty B. J. M. Cleutjens,
Guo-Ping Shi

Published: September 16, 2016
https://doi.org/10.1371/journal.pone.0162595

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