Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455

Daichao Wu; Ming Guo; Michael A. Philips; Lingzhi Qu; Longying Jiang; Jun Li; Xiaojuan Chen; Zhuchu Chen; Lin Chen; Yongheng Chen

doi:10.1371/journal.pone.0162491

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Open Access

Peer-reviewed

Research Article

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455

Daichao Wu,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Ming Guo,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Michael A. Philips,

Affiliation Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States of America
⨯
Lingzhi Qu,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Longying Jiang,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Jun Li,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Xiaojuan Chen,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Zhuchu Chen,

Affiliation Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China
⨯
Lin Chen ,

* E-mail: yonghenc@163.com (YC); linchen@usc.edu (LC)

Affiliations Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China, Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States of America
⨯
Yongheng Chen

* E-mail: yonghenc@163.com (YC); linchen@usc.edu (LC)

Affiliations Laboratory of Structural Biology, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China, Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States of America, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China
⨯

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455

Daichao Wu,
Ming Guo,
Michael A. Philips,
Lingzhi Qu,
Longying Jiang,
Jun Li,
Xiaojuan Chen,
Zhuchu Chen,
Lin Chen,
Yongheng Chen

Published: September 12, 2016
https://doi.org/10.1371/journal.pone.0162491

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